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Butordyne®

Butordyne®

Analgesic injection for dogs, cats and horses

Butordyne Injection (butorphanol tartrate) is a totally synthetic, centrally acting, narcotic agonist – antagonist analgesic with potent antitussive activity. Butorphanol is an opioid κ-partial agonist and a μ-antagonist. The effects of butorphanol last approximately 1- 3 hours. The duration of analgesia in dogs is < 1 hour and up to 2 – 3 hours in cats. Cardiopulmonary depressant effects are minimal after treatment with butorphanol as demonstrated in dogs, humans, and horses. The cardiopulmonary effects of butorphanol are not distinctly dosage-related but rather reach a ceiling effect beyond which further dosage increases result in relatively lesser effects. 

Equine Pharmacology: Following intravenous injection in horses, butorphanol is largely eliminated from the blood within 3 to 4 hours. The drug is extensively metabolised in the liver and excreted in the urine. 

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Technical Information

Active Constituent(s)

10 mg/mL butorphanol as butorphanol tartrate

(with 0.1 mg/mL benzethonium chloride preservative)

Indications

Analgesic and sedative for use in horses, dogs and cats. In cats, sedation does not occur with Butordyne Injection alone, but can occur in dogs with Butordyne Injection alone. Butordyne Injection may be used in combination with medetomidine hydrochloride and ketamine hydrochloride as a triple anaesthetic in dogs and cats. 

Dosage

 NOT TO BE USED in horses intended for human consumption. Discard unused portion 8 weeks after first broaching.

Horses:

For analgesia: The recommended dosage is 0.1 mg of butorphanol per kilogram of body weight (equivalent to 1 mL of Butordyne® Injection for each 100 kg of body weight) administered by intravenous injection. Butorphanol use should not exceed 48 hours in any one treatment episode. 

Dogs:

When administering intravenously, inject slowly: do not inject as a bolus. 

Due to the low volumes involved, great care should be taken when administering to animals weighing under 5 kg. 

For analgesia: Administer by intravenous intramuscular or subcutaneous injection routes. Dose rate: 0.2 – 0.3 mL per 10 kg (equivalent to 0.2 – 0.3 mg butorphanol per kg) body weight. Analgesic effects are seen within 15 minutes. For continuous analgesia the dose may be repeated as required. 

For sedation in combination with medetomidine hydrochloride: Butordyne Injection should be administered at 0.1 mL per 10 kg (equivalent to 0.1 mg butorphanol per kg) together with 10 – 25 μg medetomidine hydrochloride per kg body weight depending on the degree of sedation required, both by either intramuscular or intravenous injection. Allow 20 minutes for profound sedation to develop before commencing the procedure. 

For use as a pre-anaesthetic: Dose should be reduced to 0.1 – 0.2 mL per 10 kg (0.1 – 0.2 mg butorphanol per kg), given 15 minutes prior to induction. 

Cats:

Due to the low volumes involved, great care should be taken when administering Butordyne Injection to animals weighing under 5 kg. NOT recommended for intravenous use in cats under 5 kg body weight. 

For pre and post-operative analgesia: 0.2 mL Butordyne Injection per 5 kg body weight (equivalent to 0.4 mg butorphanol per kg) should be administered either by subcutaneous or intramuscular injection. 

For sedation in combination with medetomidine hydrochloride: Butordyne Injection should be administered at 0.2 mL per 5 kg body weight (equivalent to 0.4 mg butorphanol per kg) together with 50 μg medetomidine* hydrochloride per kg body weight, both by either intramuscular or subcutaneous injection.

*dose of medetomidine up to 50 ug/kg. Some situations may warrant reduced doses. 

Withholding Period(s)

Meat (Horses): Horses producing meat or offal for human consumption must not be sold for slaughter during treatment or within 63 days of the last treatment.

Product Codes

Size Code
10 mL 504270
50 mL 520355